1. | GC-MS ANALYSIS OF PHYTOCOMPONENTS IN THE ETHANOLIC LEAF EXTRACT OF syzygium samarangense |
| Manjusha MP, Gazala Parveen, G Jeyabalan |
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The presence of diverse secondary metabolites has been reported from species of the genus Syzygium. However, there has been not much information available on phytochemical components and biological activity in the ethanolic extract of leaf of Syzygium samarangense. This study was designed to determine the phytocomponents in the ethanolic extract of leaf of Syzygium samarangense. GC-MS analysis of the ethanolic extract of Syzygium samarangense was performed using a 7890 A GC with 5975C with triple axis detector and a gas chromatograph interfaced to a mass spectrometer (GC-MS). This investigation was carried out to determine the possible chemical components from Syzygium samarangense by GC-MS. This analysis revealed that the ethanol extract of Syzygium samarangense (leaf) contained mainly a 1) 2,3-Dimethylphenol, tert-butyldimethylsilyl ether; 2) Caryophyllene; 3) 2-Isopropenyl-4a,8-dimethyl-1,2,3,4,4a,5,6,7-octahydronaphthalene; 4) β-Eudesmene; 5) α-Selinene; 6) 3,7,11,15-Tetramethyl-2-hexadecen-1-ol; 7) Hexadecanoic acid, methyl ester; 8) 9-Octadecenoic acid, methyl ester; 9) Octadecanoic acid, methyl ester; 10) Methyl docosanoate; 11) Methyl tricosanoate; 12) Methyl tetracosanoate; 13) A-Neooleana-3(5),12-diene; 14) Methyl hexacosanoate; 15) Stigmastan-3,5-diene; 16) Cycloartenol acetate; 17) Lupeol acetate; 18) α-Tocopherol. From the results, it is evident so as to Syzygium samarangense contains various bioactive compounds and is recommended as a plant of phytopharmaceutical importance
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2. | IN SILICO ANTIUROLITHIATIC SCREENING OF Luffa acutangula (L) ROXB ISOLATED CONSTITUENTS |
| Preetha. S. Panicker , Gazala Parveen, G Jeyabalan |
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The bioactive compounds from ethanloic extract of Luffa acutangula L using gas chromatography–mass spectrometry and their inhibition potential against the enzyme 5FBH were studied. The research work focuses on the molecular simulations of bioactive compounds against the enzymes that acts as a potential drug target and support the drug discovery process. Eleven active compounds and their interactions with 5FBH were studied in this research work. The compounds were docked against the enzyme with the help of AutoDock vina software. Gallic acid showed the highest binding affinity values such as -7.6 with 5FBH. Protein-ligand Interaction and Visualization by Discovery studio 2020 client showed that the selected lead molecules exhibited the best interaction with the following amino acids viz. ARG A:69, THR A:406, THR A:412, TYR A:411, PRO A:407, ARG A:415,ALA A:321with 5FBH
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3. | SIGNIFICANT APPLICATION OF AEROGEL COMPOUNDS FOR ANTICANCER THERAPY |
| Deepa N*, Punithavel S, Harshini Yaamika D.S , Sanjai Prakash.B, Priyanka Jayashree S, Vignesh R, Swetha M.D , Jegatheshwaran.S , Jeevitha B.K, Hari .M |
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Aerogels are an uncommon class of nanostructured materials with exceptionally high absorbency and tuneable physicochemical belongings. Albeit a couple of sorts of aerogels have just arrived at the market in development materials, materials and aviation design, the maximum capacity of aerogels is still to be evaluated for additional innovation parts. In view of current endeavours to discourse the material gracefully restraint by a round reduced approach and life span just as personal satisfaction with biotechnological techniques, ecological and life science applications are two developing business sector openings where the utilization of aerogels should be additionally investigated and assessed in a multidisciplinary approach. The accentuation is given to the subtleties of the aerogel amalgamation and medication stacking techniques just as the impact of blend boundaries and stacking strategies on the adsorption and arrival of the medications. Inferable from their capacity to expand the bioavailability of low solvency drugs, to recover both their steadiness and their delivery energy, there are an expanding number of exploration trainings regarding aerogels in various medication conveyance requests. This audit presents a cutting-edge diagram of the improvements in a wide range of aerogel based medication conveyance frameworks which are right now underneath scrutiny.
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4. | A COMPARTIVE STUDY ON ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF AMARANTHUS ROXBURGHIANUS AND AMARANTHUS TRICOLOR |
| K.Naveen Kumari*, Anna Balaji, K.Thamizhvanan, A.Chandana, B.Srikanth, S.Ranjitha |
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Amaranthus roxburghianus and Amaranthus tricolor are traditionally well-known plants with outstanding therapeutic properties, and is used mostly in treating different diseases in India. Amaranthus roxburghianus is wild plant whose leaves and tender shoots and can be edible and are commonly used as a leafy vegetable. And used as iron tonic,its extracts or herbal formulations are rich in alkaloids ,used in traditional chinese and ayurvedic medicine. And its root combination with piperine is used in the effective treatment of inflammatory bowel disease and commonly, called as Prince?s feather (English) schirikoora (Telugu). It is also distributed in Occasional weed of waste lands and cultivated lands.Amaranthus tricolor commonly called as red amaranthus or Joseph's coat (English) and thotakura(telugu) and this plant is often cultivated in tropical and warm temperature regions,especially in Asia, for its edible leaves and seeds. The present study has to perform the antioxidant activity of both plants and compare the both plants of antioxidant activity
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