The aim of the study was to evaluation of antimicrobial activity of Theriophonum minutum plant extracts against Escherichia coli and staphylococcus aureus. The dried powder of whole plant was extracted with various solvents in increasing order of their polarity using soxhlet extraction method. Out of the extracts ethyl acetate, ethanolic and hydro-alcoholic extracts were subjected to preliminary phytochemical screening for detection of chemical constituents present in them and showed the presence alkaloids, glycosides, flavonoid, tannin and phenol, Saponin, sterol, gum and mucilage. The antibacterial activities of extracts were evaluated using the cup and plate method and the inhibitory zones were recorded in millimeters. The effect of ethyl acetate plant extracts of Theriophonum minutum plant showed the better antibacterial activity than ethanolic and hydroalcoholic extracts against E.coli and S. aureus. Zone of inhibition for ethanolic, ethyl acetate and hydroalcholic extract was found to be more for S. aureus than E.coli. Hence ethanolic extract can be further investigated for more study. Keywords: Theriophonum minutum, Antibacterial activity, Escherichia coli, Staphylococcus aureus.

For many years, the patients who are affected with acute and chronic diseases are treated with different dosage forms like tablets, pills, creams, lotions, aerosols, capsules, injection, ointments and suppositories. In the body, the concentrated drug shows less effectivity in a day when given several times for the patient. The present study was conducted is involved in the methanolic extract of the leaves like Ketaconazole and produce muco adhesive micro capsules of sodium alginate, carbopol 934 & sodium CMC to determine the physiochemical parameters and in vivo pharmacological properties