|
A series of 1-substituted analogues of 3-methyl pyrazol-5-one derivatives are synthesized by using some hydrazine
substituted analogs through the condensation & ring closure reaction with ethylacetoacetate.The synthesized pyrazoles are
subjected to analyse for physical data and IR spectral studies. The IR spectral interpretation results are correlated satisfactory
for the above synthesized compounds. They were evaluated for in-vitro anti-fungal activity by agar well diffusion method in
potato dextrose agar medium using standard drug clotrimazole 100µg concentration against Aspergillus niger (ATCC 16404)
microbial strains.The pyrazoles compounds were tested at 250?g, 500?g and 1000 ?g concentrations. Among this 3a, 3b, and
3c are sensitive, compound 3d shows less potency and 3e is not sensitive against Aspergillus niger
|
