Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2).It was first identified in December 2019 in Wuhan, China, and has since spread globally,
resulting in an ongoing pandemic. The World Health Organization (WHO) on March 11, 2020, has declared the novel
coronavirus (COVID-19) outbreak a global pandemic. According to the CDC Trusted Source, SARS-CoV-2 has an incubation
period of 2 to 14 days. This means that someone who’s carrying the virus may come into contact with many people before
symptoms begin. The virus is primarily spread between people during close contact, often via small droplets produced by
coughing,sneezing, and talking.To date, there are no specific vaccines or medicines for COVID-19 but by using some anti-viral
and anti malarial drugs such as hydrochlroquine and chloroquine it can be treated out. The epidemic preventive measures are
epidemic lockdown and social distancing

Presently, Nanotechnology is unique and fastest developing scientific fields. The results of this science have progressed
toward turning into piece of our regular day to day existences. Nanotechnology based nanomaterial‘s (NMs) have been broadly
use in cosmetics for late couple of years such as in skincare products, sunscreens, hair products, etc. This widespread impact of
nanotechnology in the cosmetic industries is due to the improved properties achieved by the particles at the nano level including
colour, transparency, solubility etc. The various types of NMs employed in cosmetics products include solid lipid nanoparticles,
liposomes, niosomes, fullerenes, etc. Nonetheless, nano-toxicological research expressed concern regarding the influence of
producing and utilization of NMs on human well-being and environment with silver nanoparticles used in hits to decrease foot
odour and are being free within the wash water causes destruction of natural biological ecosystem. Along these lines, NMs
requires a health risk assessment, which must be performed on a case-by-case basis, using pertinent information. This
comprehensive review summarizes the recent advances regarding the utilization of NMs, emphasis is made on the types of NMs
used in cosmetics by the various cosmetic brands, the potential risks caused by them each to human life and conjointly the
atmosphere and what all regulations have been undertaken or can be taken to overcome them. This review will discuss the
class, characteristics, potential health hazards, safety issues and role in way forward for NMs used in cosmetic delivery.

Andrographis paniculata (Burm.f.) Nees (Acanthaceae) is a medicinal plant traditionally used for the treatment
of cold, fever, laryngitis and several infectious diseases ranging from malaria to dysentery and diarrhoea in China, India and
other south east Asian countries. It is widely cultivated in Southern and South-eastern Asia, where it is used to treat infections
and some diseases, often being used before antibiotics were created. The plant is claimed to possess immunological, antibacterial, anti-inflammatory, anti-thrombotic and hepatoprotective properties. The chemical components present in it are
Andrographolite, neoandrographolite, and deoxyandrographlide. The derivatives of it are andrographiside, andropanoside,
andrographin and panicolin. In this review we shall be going through various aspects of this medicinal plant including its main
active constituents, microscopic evaluation and mechanisms of action

In the stage of the development of different innovative methods, quality is a prime factor of importance. The principles
of quality have been described by the International Conference on Harmonization (ICH) guidelines: Q8 Pharmaceutical
development, Q9 Pharmaceutical quality risk management and Q10 Pharmaceutical quality system. Quality-by-design (QbD) is
a recent attribute which has been added as an annex to ICH Q8. It is a scientific approach that helps to build in quality into the
product rather than testing of the final product. For the implementation of QbD various tools are needed to be used which have
been described briefly. Risk assessment approaches, process analytical technology tools and mathematical, statistical and
continuous improvement tools are important elements of quality by design, which mainly focus on the identification of critical
parameters and defining a design space statistically. The basic principles of these three ICH guidelines with regard to quality of
pharmaceutical products have been briefly discussed.

Gastric ulcer is the set of symptoms by an imbalance between the acid secreting mechanism of stomach and proximal
intestine and the protective mechanism that ensure their safety. Gastric ulcer is the damage in the lining of the stomach
corroded by the acid digestive juices which are secreted by the stomach cell. Gastric ulcer is mainly caused by infection with H.
pylori and long term use of NSAIDs and is associated with various symptoms. As incidence of the disease is increasing day by
day need to find out most effective gastro protective drug which may include the natural plant oriented medicines. In present
study we elaborated about the different medicinal plants proved to have gastro protective activity. As present allopathic drugs
are having many associated side effects needs to search for the natural drugs which are considered to have less side effects. In
India traditionally many natural plants were used for peptic ulcer. Recently many plants were studied for its gastro protective
action. Many of these plants used in peptic ulcer were evaluated by different methods like aspirin induced, endomethasone
induced etc. The present study elaborates on plants used for peptic ulcer, its extraction, model used etc

Lawsone is the main active ingredient in the henna plant that is lawsonia inermis. Based on the staining properties of
lawsone, it is mainly used for morethan 5000years as hair dye, but also applied to the body. Lawsone corresponds to 2-hydroxy-
1,4-naphthoquinone and is present at 1-2% in dried leaves of the plant. Whereas, water hyacinth flowers also used as orange red
dye. Michael addition is the process where protein keratin reacts with lawsone ingredient to obtain permanent stain on the skin
and hair until it sheds. Lawsone highly interacts with protein keratin to produce dark colored ink. In order to determine the drug
in biological fluid or in pharmaceutical preparations, there are no. of methods available, that is HPTLC, HPLC, and
spectrophotometery. The new, simple, reliable, rapid, precise ultraviolet spectrophotometric method has to validate and been
developed to analyses lawsone in bulk & poly-herbal formulation. It can be concluded that the proposed method is simple,
rapid, accurate, precise, economic and reproducible for UV spectro-photometric estimation of Lawsone from pharmaceutical
formulation. This method for routine estimation of Lawsone in bulk and pharmaceutical dosage form was successfully applied